N-Acetyl Semax Amidate is a stabilized synthetic peptide variant engineered through N-terminal acetylation and C-terminal amidation to resist enzymatic degradation and extend biological activity. This modification replaces the original peptide’s terminal carboxylic acid (-COOH) with an amide group (-NH₂), enhancing its stability.

Structurally defined as Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH₂, it demonstrates prolonged half-life (~30 minutes longer than standard Semax) and increased neuroprotective efficacy, modulating neurotransmitters like serotonin and dopamine and upregulating BDNF expression. Preclinical studies highlight its potential in cognitive enhancement, neuroregeneration, and therapeutic applications for stroke or neurodegenerative disorders.

Peptide Information