MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 14-amino acid peptide encoded by the mitochondrial genome — a rare and powerful class of peptides known as mitochondrial-derived peptides (MDPs). MOTS-c plays a key role in cellular energy regulation, fat metabolism, insulin sensitivity, and stress resistance.
Currently at the forefront of anti-aging and longevity research, MOTS-c is being explored for its ability to enhance metabolic flexibility, improve physical performance, and delay age-related decline — earning its reputation as a “mitochondrial exercise mimetic.”